The exact cause of prostate cancer remains unknown. The only well-established risk factors are age, ethnicity, and heredity.
Age is the best established risk factor for prostate cancer; the older you are, the more likely you are to be diagnosed with prostate cancer.
Hereditary Prostate Cancer
Prostate cancer, like other cancers, can be inherited. Family history and race are well-established risk factors for prostate cancer. For example, a man with a father or brother who developed prostate cancer is twice as likely to develop the disease.
Recently a rare genetic mutation has been found that is associated with prostate cancer. The mutation lies in a gene called HoxB13. Men who inherit a genetic variant in HoxB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.
It is important to know your family history to determine if you might be at increased risk for developing the disease.